Ben 10 Ultimate Alien: Cosmic Destruction is a 3D action-adventure game based on the TV series Ben 10: Ultimate Alien. It is now no longer a secret to the world that Ben is a superhero and he is now in control of the Ultimatrix. Earth is threatened by a strange Galactic storm housing a powerful evil and the power of the Ultimatrix may not be enough. Now Ben has to find several Galvan artifacts scattered around the planet to enhance the powers of the Ultimatrix.

The player takes control of Ben and can transform in to a multitude of aliens that vary in size, and abilities. Gameplay includes defeating enemies, bosses and solving puzzles. In the game various earth locations are visited like China, Paris, Tokyo and Rome. The PS3 and Xbox versions have one extra platform unique alien. The game characters are voiced by the original TV voice actors.